| 1
| Ross, Soraya | SO | Nashua South | 12.42 | 2022 Merrimack HS Invitational | May 12, 2022 | 0.6 |
| 2
| Naftali, Taryn | SR | Bedford | 12.54 | Bedford vs. Alvirne | May 10, 2022 | |
| 3
| Allard, Kristina | SR-4 | St. Paul's School | 12.65 | St. Paul's Invite | Apr 27, 2022 | |
| 4
| Kunysz, Grace | SR | Exeter | 12.67 | 2022 Merrimack HS Invitational | May 12, 2022 | 2.1 |
| 5
| Thomas, Jhanelle | FR | Nashua North | 12.68 | 2022 Merrimack HS Invitational | May 12, 2022 | 1.8 |
| 5
| Wheat, Aida | SO | Kennett | 12.68 | Coe-Brown vs Kennett, John Stark, Sanborn | Apr 21, 2022 | |
| 7
| Braswell, Iyana | JR | Nashua South | 12.69 | 2022 Londonderry R.E.A.L. Invitational | May 21, 2022 | 0.1 |
| 8
| Jenkins, Lily | SO | Portsmouth | 12.72 | 2022 Merrimack HS Invitational | May 12, 2022 | 2.0 |
| 9
| Roberts, Eva | SO | Pinkerton | 12.76 | 2022 Merrimack HS Invitational | May 12, 2022 | 1.8 |
| 10 | Sippel, Hannah | SO | Pinkerton | 12.77 | 2022 Merrimack HS Invitational | May 12, 2022 | 2.0 |
| 11 | Chavda, Anushka | JR | Coe-Brown | 12.79 | Coe-Brown vs Kennett, John Stark, Sanborn | Apr 21, 2022 | |
| 12 | Luehrs, Katherine | SR | Plymouth Regional | 12.84 | Stevens Twilight Meet | May 6, 2022 | |
| 13 | Lavelle, Sydney | SR | Exeter | 12.85 | Spaulding vs Exeter, Portsmouth | Apr 12, 2022 | |
| 14 | Dillon, Kailey | JR | Merrimack | 12.88 | 2022 Merrimack HS Invitational | May 12, 2022 | 0.9 |
| 15 | Best, Alexis | SO | Merrimack | 12.91 | 2022 Black Bear Invitational | Apr 30, 2022 | -1.2 |
| 15 | Tavarez, Rosalinda | SR | Nashua North | 12.91 | 2022 Merrimack HS Invitational | May 12, 2022 | 0.9 |
| 17 | Sinclair, Hope | SR | Winnacunnet | 12.98 | Winnacunnet vs Exeter | May 17, 2022 | |
| 18 | Young, Janiah | SR | Windsor | 13.00 | Stevens Twilight Meet | May 6, 2022 | |
| 19 | Barber, Harriet | SO | Manchester Central | 13.02 | Central & Memorial @ Concord 2022 | Apr 12, 2022 | |
| 20 | Hartson, Ella | FR | Alvirne | 13.04 | Bedford vs. Alvirne | May 10, 2022 | |
| 20 | Rodriguez, Hannah | FR | Manchester Memorial | 13.04 | Memorial, Bishop Guertin, Timberlane | May 3, 2022 | |
| 22 | Nassy, Annalise | JR | Milford | 13.06 | Home Meet #1 | Apr 12, 2022 | |
| 23 | MacPhee, Lauren | JR | Kingswood | 13.09 | Bobcat Invitational | May 14, 2022 | |
| 24 | Adigun, Fareedah | SO | Salem | 13.10 | 2022 Merrimack HS Invitational | May 12, 2022 | 1.8 |
| 24 | Ajufo, Ifeoma | SR | Phillips Exeter | 13.10 | Phillips Exeter meet #1 | Apr 16, 2022 | |
| 24 | Cooper, Caitlin | SR | Souhegan | 13.10 | 2022 Merrimack HS Invitational | May 12, 2022 | 2.1 |
| 24 | Mullen, Ayva | SO | Concord | 13.10 | Central & Memorial @ Concord 2022 | Apr 12, 2022 | |
| 28 | Masumbuko, Inesse | JR | Manchester Central | 13.11 | Central & Memorial @ Concord 2022 | Apr 12, 2022 | |
| 29 | Winslow, Emma | JR | Belmont | 13.12 | Wilderness League 2022 | May 21, 2022 | |
| 30 | Boette, Sam | SR | Wilton-Lyndeborough | 13.13 | Monadnock Twilight Meet | May 6, 2022 | |
| 31 | Cousins, Charlotte | SR | Oyster River | 13.18 | Souhegan Home April 8th | Apr 8, 2022 | |
| 31 | Malloy, Josephine | JR | Coe-Brown | 13.18 | 2022 Merrimack HS Invitational | May 12, 2022 | 0.9 |
| 33 | Cruz, Mia | JR | Nashua South | 13.20 | 2022 Nashua North HS Invitational | May 14, 2022 | -0.8 |
| 34 | Bilodeau, Sophia | FR | Bishop Guertin | 13.24 | Memorial, Bishop Guertin, Timberlane | May 3, 2022 | |
| 34 | Chirichella, Liliana | SR | Monadnock | 13.24 | Conant Mini-Meet Series #1 | Apr 12, 2022 | |
| 34 | Prokop, Payton | JR | Bedford | 13.24 | Bedford vs. Alvirne | May 10, 2022 | |
| 37 | Smith, Hannah | JR | Windham | 13.25 | Sanborn Invitational | Apr 23, 2022 | |
| 37 | Thompson, Rayna | SO | Exeter | 13.25 | 2022 Merrimack HS Invitational | May 12, 2022 | 2.0 |
| 39 | Sawyer, Sarah | SR | Milford | 13.27 | Home Meet #1 | Apr 12, 2022 | |
| 40 | Kunysz, Anna | SR | Exeter | 13.28 | Winnacunnet vs Exeter | May 17, 2022 | |
| 41 | Betournay, Paige | SR | Portsmouth | 13.29 | Dover vs Portsmouth, Winnacunnet | Apr 20, 2022 | |
| 41 | MacNeil, Tasha | SO | Con-Val | 13.29 | Milford Hosting Campbell, C-V, H-B & Sanborn | May 14, 2022 | |
| 43 | Bangasimbo, Sylvie | FR | Manchester Central | 13.31 | Central & Memorial @ Concord 2022 | Apr 12, 2022 | |
| 44 | Gholston, Ryann | JR-3 | Phillips Exeter | 13.32 | NEPSTA Division 1 T & F Championship | May 21, 2022 | |
| 45 | Wheaton, Jordan | JR | Pinkerton | 13.33 | Bishop Guertin @ Pinkerton | Apr 5, 2022 | |
| 46 | Thibault, Paige | SR | Manchester Memorial | 13.34 | Memorial, Bishop Guertin, Timberlane | May 3, 2022 | |
| 47 | Ostrowski, Emily | SR | Nashua South | 13.36 | Keene, Nashua South @ Pinkerton | May 17, 2022 | |
| 48 | Murray, Reagan | SR | Windham | 13.37 | Pelham Invitational | Apr 16, 2022 | |
| 49 | Giordano, Keely | SO | Milford | 13.39 | Home Meet #1 | Apr 12, 2022 | |
| 49 | Ogbunamiri, Sydney | SR | Merrimack | 13.39 | 2022 Merrimack HS Invitational | May 12, 2022 | 2.0 |
| 49 | Ruppel, Ava | JR | Londonderry | 13.39 | 2022 Merrimack HS Invitational | May 12, 2022 | 2.0 |
| 52 | Silveira, Hope | JR | Spaulding | 13.41 | Bobcat Invitational | May 14, 2022 | |
| 53 | Langdon, Brianna | SR | John Stark | 13.42 | Coe-Brown vs Kennett, John Stark, Sanborn | Apr 21, 2022 | |
| 54 | Durkee, Madelyn | JR | Thetford Academy | 13.44 | Stevens Twilight Meet | May 6, 2022 | |
| 54 | Sanni, Ayomide | SO | Manchester Memorial | 13.44 | Memorial, Bishop Guertin, Timberlane | May 3, 2022 | |
| 56 | MacDonald, Elle | FR | Newfound Regional | 13.45 | Wilderness League 2022 | May 21, 2022 | |
| 57 | Connors, Madison | SR | Pinkerton | 13.46 | Bow @ Pinkerton | Apr 2, 2022 | |
| 57 | Mosley, Ruthy | SR | Nashua South | 13.46 | Keene, Nashua South @ Pinkerton | May 17, 2022 | |
| 57 | Quirk, Caroline | JR | Concord | 13.46 | 2022 Merrimack HS Invitational | May 12, 2022 | 2.0 |
| 57 | Rapoza, Kylie | FR | Kingswood | 13.46 | Wilderness League 2022 | May 21, 2022 | |
| 61 | Lombardi, Mackenzie | SO | Portsmouth | 13.48 | Dover vs Portsmouth, Winnacunnet | Apr 20, 2022 | |
| 62 | Bovell, Isabella | FR | Stevens | 13.49 | KRHS Meet | Apr 21, 2022 | |
| 62 | Georgiana, Ryenne | FR | Nashua South | 13.49 | 2022 Nashua North HS Invitational | May 14, 2022 | -1.7 |
| 62 | Nkounkou, Grace | JR | Dover | 13.49 | Dover vs Portsmouth, Winnacunnet | Apr 20, 2022 | |
| 65 | Cochran, Kate | SR | Kearsarge | 13.50 | KRHS Meet | Apr 21, 2022 | |
| 65 | Madore, Gabrielle | SR | Newmarket | 13.50 | Bobcat Invitational | May 14, 2022 | |
| 67 | Parker, Tessa | JR | Windham | 13.52 | 2022 Londonderry R.E.A.L. Invitational | May 21, 2022 | 0.1 |
| 68 | Gleim, Hadley | FR | Bellows Falls | 13.54 | CVC South Qualifier At MRHS | May 10, 2022 | |
| 68 | Ortiz, Myasiah | SO | Nashua South | 13.54 | South V Bishop Guertin | May 10, 2022 | |
| 70 | Callahan, Shea | SO | Salem | 13.57 | 2022 Merrimack HS Invitational | May 12, 2022 | 2.0 |
| 71 | Dubois, Ava | JR | Bedford | 13.58 | Nashua South & Bedford @ Nashua North | Apr 13, 2022 | |
| 71 | Lovely, Maddox | FR | Newport | 13.58 | Stevens Twilight Meet | May 6, 2022 | |
| 73 | Amyot, Kayla | FR | Pembroke | 13.60 | Merrimack Valley vs Bishop Brady, Goffstown | May 12, 2022 | |
| 73 | Uwakwe, Catherine | SR | Phillips Exeter | 13.60 | Phillip's Exeter meet #2 | Apr 23, 2022 | |
| 75 | Despres, Camdyn | FR | Pembroke | 13.61 | Sanborn Invitational | Apr 23, 2022 | |
| 75 | Taylor, Kayla | JR | Concord | 13.61 | Central & Memorial @ Concord 2022 | Apr 12, 2022 | |
| 77 | Watson, Talia | FR | Belmont | 13.62 | Belmont 5/7 Sat Meet | May 7, 2022 | |
| 78 | Caceres, Malena | JR | Concord | 13.65 | Central & Memorial @ Concord 2022 | Apr 12, 2022 | |
| 78 | Poulin, Rachel | SO | Exeter | 13.65 | Spaulding vs Exeter, Portsmouth | Apr 12, 2022 | |
| 80 | Draeger, Sydney | SO | Windham | 13.66 | Southern Cluster Championships | May 17, 2022 | |
| 81 | Plante, Emily | SR | Salem | 13.67 | Salem Vs Dover and Central | May 17, 2022 | |
| 81 | Wildgoose, Kemari | 8
| Windsor | 13.67 | Doug Sargent Freshman Sophomore Invitational 2022 | May 7, 2022 | |
| 83 | Nada, Mariam | SO | Portsmouth | 13.68 | Kiwanis Freshman-Sophomore 2022 | May 7, 2022 | |
| 84 | Falcone, Claire | JR | Lebanon | 13.69 | Stevens Twilight Meet | May 6, 2022 | |
| 84 | Fayle, Brynne | JR | Kennett | 13.69 | Coe-Brown vs Pelham, Souhegan, Kennett | May 11, 2022 | |
| 84 | Wessling, Raegan | SO | Concord | 13.69 | Central & Memorial @ Concord 2022 | Apr 12, 2022 | |
| 87 | Rice, Zahna | SR | Stevens | 13.70 | CVC Qualifier 5/10 | May 12, 2022 | |
| 88 | Bell, Camryn | SO-2 | St. Paul's School | 13.72 | NEPSTA Division 1 T & F Championship | May 21, 2022 | |
| 88 | Tetreault, Samantha | FR | Pelham | 13.72 | Pembroke Home Meet May 20th | May 20, 2022 | |
| 90 | Johnson, Meranda | SO | Windsor | 13.74 | Doug Sargent Freshman Sophomore Invitational 2022 | May 7, 2022 | |
| 90 | Malatesta, Maya | JR | Bedford | 13.74 | Bedford vs. Alvirne | May 10, 2022 | |
| 90 | Minckler, Maddy | SO | Stevens | 13.74 | Newport Meet 5/2/2022 | May 4, 2022 | |
| 90 | Pulsifer, Kara | JR | Bedford | 13.74 | Bedford vs. Alvirne | May 10, 2022 | |
| 94 | Deane, Abby | JR | Oyster River | 13.75 | Bobcat Invitational | May 14, 2022 | |
| 95 | McAllister, Miah | SO | Windsor | 13.77 | Doug Sargent Freshman Sophomore Invitational 2022 | May 7, 2022 | |
| 95 | Seaman, Taylor | JR | Exeter | 13.77 | Spaulding vs Exeter, Portsmouth | Apr 12, 2022 | |
| 97 | Gridley, Rachel | SO | Concord | 13.78 | Central & Memorial @ Concord 2022 | Apr 12, 2022 | |
| 98 | Plante, Madeleine | SO | Londonderry | 13.79 | 2022 Londonderry R.E.A.L. Invitational | May 21, 2022 | 0.1 |
| 98 | Presti, Charlotte | SO | Hopkinton | 13.79 | Belmont 5/7 Sat Meet | May 7, 2022 | |
| 98 | Sovereign , Erica | SO | Windham | 13.79 | 2022 Nashua North HS Invitational | May 14, 2022 | -0.2 |
